Human Chitotriosidase-Catalyzed Hydrolysis of Chitosan
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چکیده
منابع مشابه
DNA-Catalyzed Amide Hydrolysis.
DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro selection. However, for certain reactions this identification has not been achieved. One important example is DNA-catalyzed amide hydrolysis, for which a previous selection experiment instead led to DNA-catalyzed DNA phosphodiester hydrolysis. Subsequent efforts in which the selection strategy deliberatel...
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Deoxyribozymes (DNA catalysts) have been reported for cleavage of RNA phosphodiester linkages, but cleaving peptide or DNA phosphodiester linkages is much more challenging. Using in vitro selection, here we identified deoxyribozymes that sequence-specifically hydrolyze DNA with multiple turnover and with a rate enhancement of 108 (possibly as high as 1014). The new DNA catalysts require both Mn...
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1. Shevach, E.M. Immunity 30, 636–645 (2009). 2. Yan, Z., Garg, S.K., Kipnis, J. & Banerjee, R. Nat. Chem. Biol. 5, 721–723 (2009). 3. Angelini, G. et al. Proc. Natl. Acad. Sci. USA 99, 1491–1496 (2002). 4. Castellani, P., Angelini, G., Delfino, L., Matucci, A. & Rubartelli, A. Eur. J. Immunol. 38, 2419–2425 (2008). 5. Kazama, H. et al. Immunity 29, 21–32 (2008). 6. Lim, S.Y., Raftery, M.J., Go...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2011
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi2015585